geen aandoening /
Conditions
Interventions
Participants will by randomly assigned to one of the three groups. During the
first afternoon, each group will receive two tablets, at different time points
prior to the scanning session:
- group 1
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Healthy male volunteers between 18 and 45 years of age • Predominant right-handedness • Body mass index between 18.5 and 30
Exclusion criteria
Exclusion criteria: • Abnormal (uncorrected) vision • Average use of more than 3 alcoholic beverages daily and a self-reported inability or unease to cease drinking alcohol for 24 hours prior to testing • Use of psychotropic medication • Average use or recreational drugs weekly or more • Habitual smoking, i.e. more than a package of cigarettes per week and a self-reported inability or unease to cease smoking for 24 hours prior to testing • Use of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement • Regular use of corticosteroids • Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices) • History of psychiatric treatment or current psychiatric treatment • History of neurological treatment or current neurological treatment • History of endocrine treatment or current endocrine treatment • History of autonomic failure (e.g., vasovagal reflex syncope) • Current parodontitis • Claustrophobia • Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel) • Active peptic or duodenal ulcers • Active inflammatory disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main variable of interest is the brain activity measured during the computer tasks, in combination with the cortisol levels assessed from the participant*s saliva. To determine this level participants will be asked several times during the experiment to chew on a cotton cloth in order to obtain saliva. By comparing the data between groups we will be able to elucidate the effects of cortisol on the brain and to determine the time- and region-dependency. | — |
Secondary
| Measure | Time frame |
|---|---|
| Besides brain activity we will measure several physiological and psychological measures during fMRI scanning; heart beat, blood pressure, skin conductance, pupil size, eye movement, reaction times, and the mood of the participant. These variables, in combination with personality traits assessed by several questionnaires, can be entered in the analysis of the cortisol effects as well. | — |
Countries
Netherlands
Outcome results
None listed