CD8 T-cell expansions in HIV patients, treated with HAART, who have long-term suppression of HIV-RNA

CD8 T-cell expansions in HIV patients, treated with HAART, who have long-term suppression of HIV-RNA - CD8 T-cell expansions in HIV-1 patients on HAART

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32924

Enrollment

Registered

2009-03-17

Start date

2009-06-15

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AIDS Seropositive

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -All study subjects have to be adults (18 years of age, or older) and of sound mind and judgement. -They have to be infected with HIV-1 and treated with HAART for at least 5 years. -They have to have a long-term undetectable viral load (=HIV-RNA

Exclusion criteria

Exclusion criteria: -Participants may not have had a flu, cold or any other infection at least two weeks prior to blood donation. -They may not have an active hepatitis B or C infection. -They may not use immune suppressive or immune modulating medication.

Design outcomes

Primary

Measure	Time frame
-The percentage of CD8 T-cells that is apoptosis-resistant, compared to healthy, age matched, controls.	—

Secondary

Measure	Time frame
-The percentage of CD8 T-cells that shows an exhausted phenotype, compared to healthy controls. -The copie number of HIV-1 RNA in plasma, with a test that can detect numbers as low as 5 copies per ml plasma. -The percentage of CD8 T-cells that is specific for CMV or EBV. -The TREC numbers in all subpopulations of the CD8 T-cell compartment (naive, memory and effector cells).	—

Countries

Netherlands

Outcome results