Effects of acute elevation of plasma free fatty acids on cardiac lipid accumulation in healthy lean young men

Effects of acute elevation of plasma free fatty acids on cardiac lipid accumulation in healthy lean young men - Free fatty acids and cardiac lipids

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32915

Enrollment

Registered

2008-11-19

Start date

2008-12-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac steatosis heart failure

Interventions

Subjects will perform a two-hour cycling test, once fasted (high FFA condition) and once with glucose supplementation (low FFA condition). Before and after the cycling test and again after a three-h

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: age (18-35) BMI (18-25) sex (male)

Exclusion criteria

Exclusion criteria: Contraindications for MRI (e.g. electronic implants such as pace-makers or neurostimulators, iron particles in eyes and claustrophobia)

Design outcomes

Primary

Measure	Time frame
Cardiac lipid content after the high FFA condition compared to the low FFA condition and the cardiac function and energy status associated with it.	—

Secondary

Measure	Time frame
Cardiac lipid content before exercise compared to after exercise.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)