preeclampsia & latent hypertension
Conditions
Interventions
Aerobic training (twice weekly, à 50 minutes)
training is customized to
personal physical condition (70% VO2 max). Trainingsperiod: 12 weeks
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: patients: normotensive primipara women with prior history of preeclampsia (defined as proteinuria of protein/creatinine ratio > 30 g/mol; and hypertension systolic> 140 mmHg, diastolic > 90 mmHg; diagnosed before 37 weeks gestation). ;controls: normotensive primipara women with a history of an uneventful pregnancy
Exclusion criteria
Exclusion criteria: Incapability to cope with physical exercise insulin dependant diabetes mellitus auto-immune disease Use of medication known to interfere with vascular and endothelial function Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of physical exercise in formely preeclamptic women on: - plasmavolume | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of physical exercise in formely preeclamptic women on: - venous compliance and capacity - sympathic tone - physical fitness (VO2 max) - Cardiac Output - Endothelial function measured in a.femoralis, Flow Mediated Dilatation (FMD) - Glucose lipid profile - Adaptation RAAS system - Heartfrequency - Baseline en maximal flowpatern in arterial system - observation outcome next pregnancy | — |
Countries
Netherlands
Outcome results
None listed