aangeboren kwetsbaarheid gerelateerd aan het stresssysteem (HPA-as en autonoom zenuwstelsel) attention problems Stressregulationproblems
Conditions
Interventions
A stress reduction intervention is given to the experimental group, weekly
between week 15 and 23 of gestation and each session lasts 150 minutes,
Sponsors
Universiteit van Tilburg
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Pregnant woman: -18 to 40 year old -score higher then Pc 67 on standardised stress and anxiety questionnaires -no substance abuse problems -no severe psychiatric problems -no pregnancy-related medical problems (e.g. diabetes, hypertension) or obstetrical problems;Babies -their mothers score lower than Pc 50 on standardized stress and anxiety questionnaires, measuring concurrent stress and anxiety - their mothers score lower than Pc 50 on standardized stress and anxiety questionnaires retrospectively measuring their experience of stress and anxiety during pregnancy; - the babies were full term at birth and there were no pregnancy or birth complication, no neurological impairment, congenital malformation or disease for which extensive medical treatment was needed.
Exclusion criteria
Exclusion criteria: Pregnant woman: -other medical or obstetrical complications during this pregnancy -18 to 45 year old -score lower then Pc 67 on standardised stress and anxiety questionnaires -substance abuse problems -severe psychiatric problems -pregnancy-related medical problems (e.g. diabetes, hypertension) or obstetrical problems;Babies - their mothers score higher than Pc 50 on standardized stress and anxiety questionnaires, measuring concurrent stress and anxiety - their mothers score higher than Pc 50 on standardized stress and anxiety questionnaires retrospectively measuring their experience of stress and anxiety during pregnancy; - the infants were preterm born and there were pregnancy or birth complications, neurological impairments, a congenital malformation or disease for which extensive medical treatment was needed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Part 1 (sample 1 : measuring at 10-14, 24 and 34 weeks of pregnancy) -Measures of anxiety, stress, and mindfulness with self-report questionnaires: Stress (Cohen Self Perceived Stress Scale), general anxiety (Spielberger State Trait Anxiety Scale), specific pregnancy anxiety (Pregnancy Anxiety Questionnaire-R) en Mindfulness (Five Factor Mindfulness Questionnaire) -basal HPA-as activity: saliva samples to measure cortisol awakening response and diurnal cortisol profile -basal ANS activity: saliva samples to measure alpha-amylase; 24 hrs ambulant monitoring with VU-ambulant monitoring system -stress-related HPA-axis activitity: saliva samples to measure cortisol before and after a stress-inducing arithmetic Pc-task -stress-related ANS-activity: heart rate variability (HRV) measures with commercial equipment (BIOPAC systems Inc,) before during and after a stress-inducing arithmetic Pc-task 2. Part 2 (sample 2 : measures in the four month old infant) -measuring of cognitive functioning with AERPs-paradigma -stress-related ANS activity: measures of HRV before, during and after AERPs-paradigma (with BIOPAC software) -stress-realated HPA-activity: saliva samples to measure cortisol before and after AERPs 3. Part 3 (sample 1: measure in the mother and her infant when the infant is four months old) -for the baby: the infants are tested with the protocol that is set up and fine tuned in part 2. -for the mother: well-being of the mother (psychological measurements) and basal HPA-axis activity as described in part 1; There are no ambulant recordings of ANS and no stress-induced HPA-axis of ANS activity measures. -some aspects of cognitive and socio-emotional development of the infant will be measured with subscales of the Ages and Stages Questionnaire (ASQ) and the ASQ: Social- Emotional version and an infant temperament scale (IBQ-R). These measures will be used as covariates and in some analyses also as moderators. -length of gestation, birt | — |
Secondary
| Measure | Time frame |
|---|---|
| covariates mother: maternal age, parity, gravidity, body mass index, education, SES, ethnicity, smoking, alcohol, glucocorticoid exposure, prescription drug use (i.e., SSRI, anti-hypertensive, anti-asthmatic, anti-epileptic, steroids..) | — |
Countries
Netherlands
Outcome results
None listed