Physical activity and abdominal subcutaneous adipose tissue biology in middle-aged lean and obese individuals

Physical activity and abdominal subcutaneous adipose tissue biology in middle-aged lean and obese individuals - Physical activity and biology of adipose tissue

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32843

Enrollment

Registered

2010-01-20

Start date

2010-01-15

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

total energy expenditure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Men and women - Age: 40-65 years - Body mass index: 20-25 kg/m2 and 27-35 kg/m2

Exclusion criteria

Exclusion criteria: - Body mass index 35 kg/m2 - patients with metabolic syndrome or type 2 diabetes mellitus - pregnancy or the intention to becom pregnant

Design outcomes

Primary

Measure	Time frame
The primary objective of the proposed study is to investigate the level of physical activity among lean and obese middle-aged individuals. We hypothesize that the level of physical activity among healthy (obese) subjects is higher than in patients with type 2 diabetes mellitus.	—

Secondary

Measure	Time frame
Furthermore, we hypothesize that obese and lean individuals differ with respect to smaller adipose tissue cell size, lower inflammatory markers and fat hormones expression (i.e. hsCRP, IL6/18 and leptin) in subcutaneous adipose tissue compared to patients with type 2 diabetes mellitus (prior to the start of insulin therapy).	—

Countries

Netherlands

Outcome results