geen aandoening nvt
Conditions
Interventions
Participants will be treated with biperiden, ATD, a combination, or a placebo.
The biperiden will be administered orally with a capsule. The ATD consists of a
gelatine-based protein drink that parti
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: male or female, between 18-35 years of age, healthy (absence of exclusion criteria), normal static binocular activity, body mass index between 18.5 and 30, willingness to sign an informed consent.
Exclusion criteria
Exclusion criteria: history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| A further important parameter is the change in behavioural and brain response to the choice reaction time task, since this measures a possible sedative effect of the two manipulations. Finally, we will measure the event-related potential during a novelty oddball task to assess the role of both neurotransmitters in novelty processing. | — |
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the behavioural score on the verbal learning task, the continuous recognition memory task, and the spatial memory task. Secondary, the event-related potentials during those tasks will be analysed. | — |
Countries
Netherlands
Outcome results
None listed