Nocturnal free fatty acids. Measurements in obese and lean subjects and the effect of beta-blockage on pulsatile release.

Nocturnal free fatty acids. Measurements in obese and lean subjects and the effect of beta-blockage on pulsatile release. - Nocturnal free fatty acids

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32829

Enrollment

Registered

2008-12-03

Start date

2009-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

insulin resistance

Interventions

Each subject will be studied twice in random assignment. They will receive propranolol or saline intravenously for 12 hours during one night.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Kaukasische man met een BMI > 30 kg/m2 of een BMI 20

Exclusion criteria

Exclusion criteria: * any chronic medical condition or use of any medication * asthma and bronchospastic COPD * tobacco use * alcohol abuse (>3/day) * frequent intensive exercise (>2 week) * familial lipid disorders, renal insufficiency (creatinine > 150 umol/L) , elevated liver enzymes (> 2 times), hypertension * Hypotension (BP

Design outcomes

Primary

Measure	Time frame
1. Percent and/or absolute changes in nocturnal FFA levels with or without *- blockage. 2. Difference in nocturnal FFA levels between lean and obese subjects.	—

Secondary

Measure	Time frame
Phenotypical differences (adipose tissue distribution, plasma parameters)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)