The essential role of speech motor regions in processing variation in speech: a Transcranial Magnetic Stimulation study

The essential role of speech motor regions in processing variation in speech: a Transcranial Magnetic Stimulation study - TMS for speech comprehension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32812

Enrollment

Registered

2008-11-28

Start date

2008-10-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

niet van toepassing nvt.

Interventions

In the TMS sessions in the pilot experiment we will stimulate the left vPMC with either of two paradigms: participants either receive 10 minutes of 1 Hz rTMS to left vPMC, or 40 seconds of triplets

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Right-handed Native speakers of Dutch

Exclusion criteria

Exclusion criteria: Epilepsy Metal in the body Pacemaker Pregnancy

Design outcomes

Primary

Measure	Time frame
The effect of TMS on the three stimulation sites in the main experiment will be assessed using a behavioural task, i.e., a response time (RT) task in which the difference in RT and the proportion of correct responses are the dependent variables. In one condition, listeners hear sentences in a familiar accent, and in a second condition they hear sentences in an unfamiliar regional accent. The main study parameter is the difference in RT across conditions before and after TMS. The proportion of errors is the secondary parameter. It is predicted that RTs are slower for the unfamiliar regional accent and an interaction is expected between condition and pre-and post stimulation to left vPMC, resulting in a further slowing down of RTs for the unfamiliar accent after stimulation.	—

Measure

Time frame

The effect of TMS on the three stimulation sites in the main experiment will be assessed using a behavioural task, i.e., a response time (RT) task in which the difference in RT and the proportion of correct responses are the dependent variables. In one condition, listeners hear sentences in a familiar accent, and in a second condition they hear sentences in an unfamiliar regional accent. The main study parameter is the difference in RT across conditions before and after TMS. The proportion of errors is the secondary parameter. It is predicted that RTs are slower for the unfamiliar regional accent and an interaction is expected between condition and pre-and post stimulation to left vPMC, resulting in a further slowing down of RTs for the unfamiliar accent after stimulation.

—

Secondary

Measure	Time frame
The secondary parameter are the motor evoked potentials (MEPs), which are measured every 3 minutes immediately after the two types of stimulation in the pilot experiment for 30 minutes. This results in 10 measurements for each cortical site per participant.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)