psychosis schizophrenia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: A total of 40 Patients must have a diagnosis within the schizophrenia spectrum, either schizophrenia or schizophreniform disorder. A total of 40 patients must have a diagnosis within the mood disorders, either bipolar disorder or psychotic depression. All patients must have a history of psychosis as we are interested in insight in psychosis. All subjects must be cooperative, capable of lying still in a scanner for one hour and capable of performing the experimental tasks.
Exclusion criteria
Exclusion criteria: Patients may not use classical antipscychotic medication as it has been shown that this type of medication can influence the activation in the frontal cortices. Furthermore, patients may use a maximum of three Lorazepam equivalents, since they must be alert enough to perform the experimental tasks. Patients must be stable on their current medication and may not have had a change in medication in the week before scanning. In addition, patients may not have the diagnosis schizoaffective disorder as this diagnosis has been controversial, difficult to diagnose and patients who have had this diagnosis are often diagnosed with schizophrenia later in life. All subjects may not have a 'relevant' neurological disorder affecting the Central Nervous System for which they are treated nor may the psychiatric diagnosis have a somatic origin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are signal change in bold responses in self-evaluation and emotion regulation processes in relation to illness insight. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are behavioural differences between groups in terms of percentages correct and reaction times regarding the experimental tasks. | — |
Countries
Netherlands
Outcome results
None listed