Addison's disease primary adrenal insufficiency
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - primary adrenal insufficiency - 18-70 years - stable glucocorticoid replacement therapy (no adjustments of regime and dosage for 3 months)
Exclusion criteria
Exclusion criteria: - intercurrent infectious or serious disease for which it is necessary to increase glucocorticoid dosage - high dose inhalation glucocorticoids (>800 microgram a day) - pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Presence of metabolic syndrome (3 or more abnormalities of waist circumference, blood pressure, triglycerides, HDL cholesterol, glucose) 2) Quality of life score | — |
Secondary
| Measure | Time frame |
|---|---|
| Presence of glucocorticoid receptor polymorfisms and GRT in relation to the metabolic syndrome and QoL. | — |
Countries
Netherlands
Outcome results
None listed