Uisng changes in pulmonary mechanics and gas exchange to better define the optimal pulmonary volume in patients ventilated for acute lung injury

Uisng changes in pulmonary mechanics and gas exchange to better define the optimal pulmonary volume in patients ventilated for acute lung injury - Pulmonary mechanics to better define the optimal pulmonary volume in ALI

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32764

Enrollment

Registered

2008-10-14

Start date

2008-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS respiratory insufficiency

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria * Mechanically ventilated * Have lung pathology (either primary or secondary) who fulfil the definition of Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS) -see below * And their parents agree for them to participate in the study and give given written informed consent

Exclusion criteria

Exclusion criteria: * Children ventilated for an obstructive lung pathology * Children with raised intracranial pressure or a head injury

Design outcomes

Primary

Measure	Time frame
* Comparison of pulmonary physiological, circulatory, and ventilatory parameters in each patient, enabling correlation between these parameters: haemodynamic parameters, blood gas analysis including oxygen saturation, PaO2/ FiO2, v CO2, opening pressure, closing pressure, oesophageal pressure, plus during CMV we will also measure dynamic compliance, elastance, respiratory inductance plethysmography and deadspace. * Correlation of PEEP/MAP and the TPP with currently used markers indicating achievement optimal lung volume (pO2, p CO2, dynamic compliance, deadspace). * Comparison of two groups * to compare above parameters between the two groups of primary and secondary ARDS	—

Measure

Time frame

* Comparison of pulmonary physiological, circulatory, and ventilatory parameters in each patient, enabling correlation between these parameters: haemodynamic parameters, blood gas analysis including oxygen saturation, PaO2/ FiO2, v CO2, opening pressure, closing pressure, oesophageal pressure, plus during CMV we will also measure dynamic compliance, elastance, respiratory inductance plethysmography and deadspace. * Correlation of PEEP/MAP and the TPP with currently used markers indicating achievement optimal lung volume (pO2, p CO2, dynamic compliance, deadspace). * Comparison of two groups * to compare above parameters between the two groups of primary and secondary ARDS

—

Secondary

Measure	Time frame
bloodgasses, hemodynamics	—

Countries

Netherlands

Outcome results