DOSING AND PHARMACOKINETICS OF INTRAVENOUS AMOXICILLIN IN CHILDREN

DOSING AND PHARMACOKINETICS OF INTRAVENOUS AMOXICILLIN IN CHILDREN - dosing/pharmacokinetics of intravenous amoxicillin in children

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32761

Enrollment

Registered

2010-02-17

Start date

2010-12-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bacterial infectious diseases

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. Patients who receive intravenous treatment with amoxicillin 2. Patients

Exclusion criteria

Exclusion criteria: Patients with a known allergy to amoxicillin or related compounds

Design outcomes

Primary

Measure	Time frame
Primary parameters in this study will be: * T1/2 (half-life during elimination phase) and Vss (volume of distribution in steady state) of amoxicillin * Total body clearance, AUC (area under the time-concentration curve), MRT (mean residence time) Interpretation of pharmacokinetic parameters * Plasma concentrations and the AUCs of amoxicillin will be compared to the MIC (minimal inhibitory concentration) of the microbe to be eliminated. T1/2 of amoxicillin will be related to the GFR (glomerular filtration) * All pharmacokinetic parameters will be related to the personal characteristics of the subjects Finally, all data will lead to a new dosing advice on intravenous amoxicillin treatment in children.	—

Measure

Time frame

Primary parameters in this study will be: * T1/2 (half-life during elimination phase) and Vss (volume of distribution in steady state) of amoxicillin * Total body clearance, AUC (area under the time-concentration curve), MRT (mean residence time) Interpretation of pharmacokinetic parameters * Plasma concentrations and the AUC*s of amoxicillin will be compared to the MIC (minimal inhibitory concentration) of the microbe to be eliminated. * T1/2 of amoxicillin will be related to the GFR (glomerular filtration) * All pharmacokinetic parameters will be related to the personal characteristics of the subjects Finally, all data will lead to a new dosing advice on intravenous amoxicillin treatment in children.

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Countries

Netherlands

Outcome results