Determining the role of Von Willebrand factor and ADAMTS13 in the adhesion of sickled erythrocytes to endothelial cells

Determining the role of Von Willebrand factor and ADAMTS13 in the adhesion of sickled erythrocytes to endothelial cells - The role of VWF and ADAMTS13 in vascular occlusion in sickle cell disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32743

Enrollment

Registered

2009-11-26

Start date

2009-10-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hereditary anemia sickle cell disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult sickle cell patients with HbSS or HbS*0 als genotype

Exclusion criteria

Exclusion criteria: Therapeutic intervention with hydroxyurea (Hydrea), with an extra exclusion criterium for the non-transfused patients that they have not been transfused in the last 4 months.

Design outcomes

Primary

Measure	Time frame
Main study parameter is the amount and percentage of adhesion as compared to a baseline measurement with normal erythrocytes.	—

Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results