An explorative study on cortical activation in normal hearing and in deaf adults, before and after cochlear implantation, measured with fMRI and NIRS.

An explorative study on cortical activation in normal hearing and in deaf adults, before and after cochlear implantation, measured with fMRI and NIRS. - Measurement of cortical hemodynamics using fMRI or NIRS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32742

Enrollment

Registered

2008-09-18

Start date

2008-08-18

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sensorineural hearing loss severe hearing loss and deafness

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Adults (18 years of age or older) 2. Right handed 3. Normal hearing group: having a pure-tone air conduction thresholds 50% (open-set monosyllable lists according to the *Nederlandse Vereniging van Audiologie* (NVA)). b. Implanted group with poor results: consonant-vowel-consonant (CVC) score

Exclusion criteria

Exclusion criteria: 1.Pregnancy/breastfeeding 2.Subjects with intracorporeal metal components or electronic devices 3.Claustrophobic

Design outcomes

Primary

Measure	Time frame
A fMRI scan measured the cerebral blood flow (and hence the cortical activity) by differences in the regional Blood Oxygen Level Dependent (BOLD) response between activated and baseline (or control) condition. To study the brain activity with NIRS, local changes in cortical oxy- and deoxyhemoglobin concentration are evaluated.	—

Countries

Netherlands

Outcome results