animarum tibiarum Ekbom syndrome restless legs
Conditions
Interventions
None listed
Sponsors
Medisch Centrum Haaglanden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria PD patients with RLS 1.Fulfillment of the United Kingdom PD Society Brain Bank criteria for idiopathic PD. 2.Definite RLS in which all four revised minimal criteria of RLS are fulfilled based on an personal history taken by a RLS trained investigator/ doctor;Inclusion criteria PD without RLS 1.Fulfillment of the United Kingdom PD Society Brain Bank criteria for idiopathic PD. 2.Definite no diagnosis of RLS based on a personal history taken by a RLS trained investigator/ doctor 3.Age, sex , PD severity (Hoehn & Yahr and total levodopa-equivalent) matched to the PD patients with RLS;Inclusion criteria of RLS without PD 1.Definite RLS in which all four revised minimal criteria of RLS are fulfilled based on an personal history taken by a RLS trained investigator/ doctor 2.All secondary RLS patients are excluded besides iron deficiency related RLs 3.Age and sex matched to the PD patients;Inclusion criteria healthy controls 1. Definite no RLS or other known diseases 2. Age and sex matched to the RLS patients without PD
Exclusion criteria
Exclusion criteria: 1.No temporal bone window to perform a qualitatively good transcranial sonography 2.Iron medication 3.Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the echogenicity of the substantia nigra, red nucleus and brain stem raphe in these four groups | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the serum iron status in these four groups To determine the relation between echogenicity and iron status in the four groups | — |
Countries
Netherlands
Outcome results
None listed