From Gene to Neural Function in ADHD. Enriching the Dutch Database of the International Multisite ADHD Genetics (IMAGE) Project.

From Gene to Neural Function in ADHD. Enriching the Dutch Database of the International Multisite ADHD Genetics (IMAGE) Project. - From Gene to Neural Function in ADHD.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32726

Enrollment

1000

Registered

2008-09-10

Start date

2008-10-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD attention-deficit/hyperactivity disorder

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Previous inclusion criteria: ADHD-families: at least one proband with the combined subtype of ADHD and at least one sibling and one parent available for testing. Children between the ages of 5 and 18 were included. Control-children: no ADHD and no ADHD in their first-degree relatives. Children between the ages of 5 and 18 were included.;For the current follow-up: all children are contacted and tested again, regardless of previous in- and exclusion criteria allowing for studying remitted cases of ADHD (or new ADHD cases in the control group).

Exclusion criteria

Exclusion criteria: (1) IQ

Design outcomes

Primary

Measure	Time frame
Assessments will be scheduled 5 to 6 years after the baseline assessments. sMRI (30 min) and fMRI (60 min, while presenting the stop-task and a spatial working memory task) data will be acquired. Phenotyping will follow similar procedures as at baseline, and include a semi-structured investigator-based interview to categorically classify ADHD, and questionnaires to obtain dimensional scores of ADHD symptoms and related comorbidity. Outside the scanner, 8 other neuropsychological tasks will be administered to the children (set-shifting, verbal working memory, time reproduction, motor timing, motor control, motor speed, intelligence, and positive and negative reinforcement). Parents will be assessed using the same 10 neuropsychological tasks outside the scanner, and be phenotyped using questionnaires.	—

Measure

Time frame

Assessments will be scheduled 5 to 6 years after the baseline assessments. sMRI (30 min) and fMRI (60 min, while presenting the stop-task and a spatial working memory task) data will be acquired. Phenotyping will follow similar procedures as at baseline, and include a semi-structured investigator-based interview to categorically classify ADHD, and questionnaires to obtain dimensional scores of ADHD symptoms and related comorbidity. Outside the scanner, 8 other neuropsychological tasks will be administered to the children (set-shifting, verbal working memory, time reproduction, motor timing, motor control, motor speed, intelligence, and positive and negative reinforcement). Parents will be assessed using the same 10 neuropsychological tasks outside the scanner, and be phenotyped using questionnaires.

—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results