Effects of leptin therapy on hypothalamic structure and function in congenital lipodystrophy

Effects of leptin therapy on hypothalamic structure and function in congenital lipodystrophy - Hypothalamic effects of leptin

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32723

Enrollment

Registered

2008-10-07

Start date

2008-10-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

congenital lypodystrophy

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: >5 years of age Negative pregnancy test appropriate birth control confirmed congenital lipodystrophy diabetes hypertriglyceridemia If >18 years of age: able to read, understand and sign Informed consent form

Exclusion criteria

Exclusion criteria: HIV liverinfection allergy to E.coli-derived proteins

Design outcomes

Primary

Measure	Time frame
The hypothalamic BOLD signal before and during leptine therapy. Hypothalamic structure before and afduring leptine therapy (7 Tesla MRI)	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results