geen aandoening nvt
Conditions
Interventions
Participants will be treated with citalopram, rivastigmine, a combination, or a
placebo. Both medications will be administered orally with a capsule. The
treatment order will be established by count
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or female, between 18-35 years of age, healthy (absence of exclusion criteria), normal static binocular activity, body mass index between 18.5 and 30, willingness to sign an informed consent.
Exclusion criteria
Exclusion criteria: History of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the behavioural score on the verbal learning task (VLT), the continuous recognition memory task (CRMT), and the spatial memory task (SMT). Secondary, the event-related potentials during those tasks will be analysed. | — |
Secondary
| Measure | Time frame |
|---|---|
| A further important parameter is the brain response during a novelty oddball task, because both neurotransmitters may also be involved in novelty processing. | — |
Countries
Netherlands
Outcome results
None listed