nocturnal GERD nocturnal heartburn
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Man and woman > 18 years of age - Proven nocturnal GERD (pH 3 % of supine position) - Non-obese subjects: BMI 18.5-24.9 kg/m2 - Obese subjects: BMI > 30 kg/m2
Exclusion criteria
Exclusion criteria: - Pre-existent esophageal motility disorders - Proven obstructive sleep apnea with CPAP therapy - Inability to stop medication that affects the motility of the upper gastrointestinal tract (anti-cholinergic drugs, theophylline, calcium blocking agents, opioids)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in nocturnal reflux pattern (reflux time / 24 h, frequency of reflux episodes, LES pressure) between obese and normal-weight subjects with GERD. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.v.t. | — |
Countries
Netherlands
Outcome results
None listed