Milde cognitieve stoornissen (geheugenpoli) Mild cognitive impairment preclinical dementia
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients should have a least an impairment in the memory domain, with a CDR score 0.5, whereas participants in the control group should be cognitive healthy as determined by neuropsychological assessments. For both groups, the age range is between 58-68 years old. Only male patients will be included, who are right-handed or ambidexter and who have an average level of education. Participants have to fill in an informend consent and a screening questionnaire that contains questions about home adress, age, handedness, sensory functioning, profession, educational level, lifestyle, health and MRI-exclusion criteria
Exclusion criteria
Exclusion criteria: Participants who do not fulfill the MRI-safety criteria are not allowed in the study Furthermore, people with reduced vision, psychoactive medication use, substance abuse, past or present psychiatric or neurological disorders and structural abnormalities in the brain are not included in the study. Control participants with neuropsychological test results below average (based on normative data) will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome measures are performance (mean reaction time and accuracy) and the Blood Oxygen Level Dependent (BOLD) response during the functional tasks. Firstly, the differences in BOLD response between groups will be calculated. Secondly, the functional network underlying this performance will be analyzed by using fractional anisotropy measures and granger causality mapping. | — |
Secondary
| Measure | Time frame |
|---|---|
| White matter lesions will be taken in consideration and resting state connectivity will be analyzed | — |
Countries
Netherlands
Outcome results
None listed