focus op het gezonde brein niet van toepassing
Conditions
Interventions
80 milligram propranolol in a capsule (once only). Propranolol is a
non-selective beta-blocker mainly used in the treatment of hypertension, but
also often used by musicians and other performers to
Maheu, Joober, & Lupien, 2005
van
Stegeren et al., 2005) and we intend to use a single dose only. Metabolism
occurs mainly by means of the kidneys. The biological half-life is 3-6 hours.
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult subjects between the ages 18 and 30 with no history of neurological disorder/disease and normal blood pressure and heart rate will be included in this study. All participants will be right-handed native Dutch speakers.
Exclusion criteria
Exclusion criteria: Low blood pressure, bradycardia, cardiac arrhythmia, severe pulmonary conditions, head trauma, learning disabilities, and history of neurological or psychiatric illness and/or use of (psychotropic) medication. Further, subjects with Dutch as a second language and left-handed individuals will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the EEG measurement. The endpoint is the effect of propranolol on the EEG signal. We hypothesize that propranolol will decrease the amplitude of the different components of the EEG signal that we investigate. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameter is subsequent memory (% correctly recognized stimuli after the 2 week interval). The endpoint is the effect of propranolol on subsequent memory. We hypothesize that subsequent memory will be better for emotional than for neutral stimuli (higher % correctly recognized stimuli after the 2 week interval) and that this difference will decrease because of propranolol. | — |
Countries
Netherlands
Outcome results
None listed