autism autistic disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: General Inclusion criteria 1) Aged at least 4 years ;Inclusion criteria for subjects with ASD 2) DSM-IV (APA, 1994) diagnosis in the autism spectrum, according to ADI-R interview and ADOS;Inclusion criteria for controls 2) No psychiatric disorders or behavioural problems as reflected by scores on the CBCL in the normal range. 3) no significant social problems as reflected by a score on the SRS in the normal range 4) No ASD in their first degree relatives. 5) IQ > 70
Exclusion criteria
Exclusion criteria: Exclusion criteria 1) Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system 2) History of or present neurological disorder 3) For individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study parameters/outcome of the study: The parameters of the study are the genotype of common variants for ASD, possible CNVs and gene-expression patterns. The outcome measures are specific subtypes of ASD revealed by clustering of neuropsychological and behavioural symptoms as well as the severity of symptoms as measured with specific clinical instruments (questionnaires, diagnostic interview and observation-instrument and neuropsychological tasks (see chapter clinical phenotyping). | — |
Secondary
| Measure | Time frame |
|---|---|
| None | — |
Countries
Netherlands
Outcome results
None listed