major depressive disorder (recurrent) recurrent depression
Conditions
Interventions
Combination of mindfulness based cognitive therapy (MBCT) and optimised medical
management (OMM), OMM alone and MBCT alone.
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with major depressive disorder with at least three previous depressive episodes. Patients have been treated with a therapeutic dose of antidepressant medication over the last 6 months. Patients are currently either in full or partial remission.
Exclusion criteria
Exclusion criteria: Bipolar disorder Any primary psychotic disorder Clinically relevant neurological or other somatic illness Current alcohol or drug misuse Use of high dosage of benzodiazepines (>2 mg lorazepam equivalents daily) Recent Electro Convulsive Therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure: risk of relapse or recurrence of depression defined by DSM-IV criteria as assessed by the Structured Clinical Interview for DSM-IV (SCID; First et al., 1996) and incremental cost-effectiveness ratio. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures: time to, duration and severity of relapse or recurrence as assessed by the Inventory of Depression Symptomatology Self Rated (IDS-SR; Rush et al., 1996), psychiatric comorbidity and quality of life. | — |
Countries
Netherlands
Outcome results
None listed