respiratory tract inflammation thrombogenesis
Conditions
Interventions
None listed
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy, non smoking, 18-35 years of age, living in students housing facilities at the campus of Utrecht University (de Uithof), good understanding of the Dutch language
Exclusion criteria
Exclusion criteria: lifetime diagnosis asthma or COPD recent wheeze, shortness of breath, chronic cough history of high blood pressure, angina pectoris or myocardial infarction medication for respiratory or cardiovascular disease diabetes mellitus obesity smoking or living in a household with a smoker pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory and cardiovascular health will be assessed before and after the exposure. These will include recording of symptoms, spirometry (peakflow, FEV1, FVC, FEF25-75), nasal lavage, exhaled NO and CO, blood pressure, oxygen saturation in blood, heart rate, and blood sampling. Plasma samples and nasal lavage will be analyzed on inflammation markers. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will administer a time activity questionnaire to assess exposure to indoor sources (e.g. smoking, cooking), participation in traffic, and time spent outdoors. These measurements will be used to document the relative contribution of pre- and post experiment exposures, compared to exposure during the experiment. | — |
Countries
Netherlands
Outcome results
None listed