psychostimulantia zonder beoogd effect op aandoening bij adolescenten N/A (see C21)
Conditions
Interventions
Caffeine (approximately 135 mg caffeine in Nespresso coffee) or placebo (
Sponsors
Centre for Human Drug Research
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Written informed consent from parents having parental responsibility or from legal guardian. Written informed consent from child. Aged 15-18 (extremes including). Able to communicate with the investigator in Dutch. Non-smoker.
Exclusion criteria
Exclusion criteria: Any significant medical condition that in the opinion of the medical investigator would be a contraindication for the use of caffeine and/or would interfere with the study objectives. Cannabis use 7 days before the study days (by medical history). Alcohol use of more than 14 units per week (by medical history). Daily use of more than 5 units of xanthine-containing food products or drinks (including but not limited to coffee, tea, Red Bull, chocolate). Distaste of coffee.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacodynamics: - Results of neurocognitive and psychomotor test (including adaptive tracking, smooth eye pursuit, saccadic eye movement, finger tapping, choice reaction task, critical flicker fusion task, attention switching task, body sway, and visual verbal learning test) - Autonomic nervous system parameters (including heart rate, blood pressure, and pupil size) Pharmacokinetics: caffeine concentrations in saliva | — |
Secondary
| Measure | Time frame |
|---|---|
| Results of a short questionnaire which will be taken after completion of the neurocognitive tasks on how volunteers experienced participation. | — |
Countries
Netherlands
Outcome results
None listed