Muscle metabolism during exercise in children with Juvenile Dermatomyositis and the relationship with inflammation

Muscle metabolism during exercise in children with Juvenile Dermatomyositis and the relationship with inflammation - Muscle metabolism & exercise JDM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32652

Enrollment

Registered

2008-11-04

Start date

2010-05-07

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Juvenile Dermatomyositis (JDM) muscle arthritis

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Diagnosed juvenile Dermatomyositis, between 12- 18 years of age, clinical remission has been diagnosed by the attending physician, signed informed consent by patient and parents/ legal representatives. Inclusion criteria healthy subjects: healthy, active lifestyle, signed informed consent by subject and parents/ legal representatives

Exclusion criteria

Exclusion criteria: Diagnosed polymyositis or myositis with MCTD, active myositis, age 18 years, no informed consent Exclusion criteria healthy subjects: history of muscle disease, chronic medication usage, underlying auto-immune disease (e.g. JIA, SLE, MCTD), no informed consent

Design outcomes

Primary

Measure	Time frame
In 5 patients with JDM (and the 5 healthy controls) there will be studied whether there are difference demonstrable concerning the muscle energetics in the proximal leg muscles during a recumbent bicycle-exercise test in a MR scanner (using 31P MRS) as a measure for an efficient metabolism. The following parameters will be determined: (i) Phosphocreatin/ anorganic Phosphate (PCr/Pi) ratio at different levels of exercise load (ii) Glycolytic intermediary metabolite concentration (mono-phosphorylised glucose) during different levels of exercise load (iii) Acidity (pH value) at different levels of exercise load (iv) Energy usage (ATP turnover; mm/s) during different levels of exercise load (v) ATP buffer (PCr) re-synthesis speed during recovery after exercise	—

Measure

Time frame

In 5 patients with JDM (and the 5 healthy controls) there will be studied whether there are difference demonstrable concerning the muscle energetics in the proximal leg muscles during a recumbent bicycle-exercise test in a MR scanner (using 31P MRS) as a measure for an efficient metabolism. The following parameters will be determined: (i) Phosphocreatin/ anorganic Phosphate (PCr/Pi) ratio at different levels of exercise load (ii) Glycolytic intermediary metabolite concentration (mono-phosphorylised glucose) during different levels of exercise load (iii) Acidity (pH value) at different levels of exercise load (iv) Energy usage (ATP turnover; mm/s) during different levels of exercise load (v) ATP buffer (PCr) re-synthesis speed during recovery after exercise

—

Secondary

Measure	Time frame
The ratios between the measured VO2 piek and CO2 piek are determined in relation to maximal power (Wmax), to describe a unit of measure for the so-called mechanical efficiency of the muscles.	—

Countries

Netherlands

Outcome results