n.v.t. n.a.
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: between 18 - 40 years of age male and female normal vision and hearing right handed people without musical training
Exclusion criteria
Exclusion criteria: 1. Individuals learned to play a musical instrument, or had singing lessons 2. left handedness 3. MR incompatible implants in the body 4. Neurological complaints present as well as past 5. Use of drugs that may influence the task performance 6. Claustrophobia 7. Wishes not to be informed of brain abnormalities that may be noticed in the scans 8. (Suspected) Pregnancy 9. Red tattoos The fMRI exclusioncriteria will be checked by way of a questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter will be the hemodynamic response measured with fMRI. More specifically, the repetition suppression effect, which is due to repeated presentation of stimuli will be analyzed. This effect will be compared for the different experimental conditions (please see study design). The visual mirror system will be determined by identifying the areas that show a repetition effect in the experimental condition (1) Vtrain Vtest. The auditory mirror system will be determined by identifying the areas that show a repetition effect in the experimental condition (4) Atrain Atest. For the comparison of the experimental conditions 1, 2 and 3, we hypothesize that within the areas of the visual mirror system the repetition suppression effect will be largest for (1) Vtrain Vtest, diminished in (2) Atrain Vtest and smallest for (3) no-train Vtest. Analogously we expect that within the areas of the auditory mirror sytem the repetition suppression effect will be largest for (4) Atrain Atest, diminished in (5) Vtrain Atest and smallest for (6) no-train Atest. In the third fMRI scan, we test whether there are trimodal brain areas by examining the crossmodal repetition effect. This will be done by identifying areas that show a repetition suppression effect when sequences will be presented successively auditorily and visually. We expect that overlapping areas of the auditory and the visual mirror system show a crossmodal repetition suppression effect. | — |
Secondary
| Measure | Time frame |
|---|---|
| Furthermore, we analyze properties of the integrity of white matter tracts reflected by the fractional anisotropy (FA) for the directional dependence of water diffusion. These values will be correlated with learning parameter (e.g., learning time for the key sequences) as well as with the individual hemodynamic responses in brain areas which show a repetition suppression effect. | — |
Countries
Netherlands
Outcome results
None listed