Diabetes Insulin resistance
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - written informed consent - Caucasian - able to keep a normal day and night rhythm during the study period (i.e. no shift work) - stable weight for at least 3 months - age 20-55 years AND Inclusion criteria for healthy volunteers: - 20 * BMI * 25 kg/m2 - fasting glucose level of 30 kg/m2 - fasting glucose level of 2.7
Exclusion criteria
Exclusion criteria: - participation in an investigational drug trial within 90 days prior to our study - history of or current abuse of drugs or alcohol (>14 U/week) - smoking - vigorous physical activity - family history of DM II - familial dyslipidemia - any medical condition except hypertension and dyslipidemia in the obese group - use of any medication except for anti-hypertensives, excluding ACE-inhibitors/AII-antagonists
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Peripheral insulin sensitivity - GM3 concentration in skeletal muscle and abdominal adipose tissue | — |
Secondary
| Measure | Time frame |
|---|---|
| - plasma concentration of glucoregulatory hormones - energy expenditure - carbohydrate oxidation and fat oxidation - VO2 max - Muscle fiber type | — |
Countries
Netherlands
Outcome results
None listed