Ethnic differences in vascular contractility and remodeling.

Ethnic differences in vascular contractility and remodeling. - Ethnic differences in vascular contractility.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32640

Enrollment

Registered

2008-11-24

Start date

2008-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

high blood pressure hypertension.

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Ethnicity Age Normotension Abdominal surgery

Exclusion criteria

Exclusion criteria: Vasculitis Diabetes HIV Hepatitis B en C Hypertension Cardiovascular diseases Bleeding tendency or use of anticoagulation medication (except incidental apspirine)

Design outcomes

Primary

Measure	Time frame
Primary Outcome Measure: Ethnic difference in maximum endothelium-dependent relaxation.	—

Secondary

Measure	Time frame
Secondary Outcome Measures Ethnic differences in: 1. Creatine kinase activity in vessels and in blood. 2. Vessel wall thickness as assessed by histological examination with light microscopy and electron microscopy. 3. The maximal contraction at optimal diameter 4. noradrenalin contractility, vasodilatation in response to endothelium-dependent bradykinin, calcium blockade, NO donation and creatine kinase inhibition will be studied. 5. The response of the vessel wall to vessel culture.	—

Measure

Time frame

Secondary Outcome Measures Ethnic differences in: 1. Creatine kinase activity in vessels and in blood. 2. Vessel wall thickness as assessed by histological examination with light microscopy and electron microscopy. 3. The maximal contraction at optimal diameter 4. noradrenalin contractility, vasodilatation in response to endothelium-dependent bradykinin, calcium blockade, NO donation and creatine kinase inhibition will be studied. 5. The response of the vessel wall to vessel culture.

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Countries

Netherlands

Outcome results