The effect of nasal provocation on clinical response and nasal inflammatory parameters in nonallergic rhinitis, mixed rhinitis and allergic rhinitis patients versus healthy individuals

The effect of nasal provocation on clinical response and nasal inflammatory parameters in nonallergic rhinitis, mixed rhinitis and allergic rhinitis patients versus healthy individuals - Nonallergic rhinitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32628

Enrollment

Registered

2008-12-22

Start date

2009-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-allergic rhinitis and non-allergic nasal complaints

Interventions

The four studygroups will undergo equal interventions. During the provocationvisits, nasal provocations will take place with three different entities. The provocation with capsaicin nasal spray will

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: male or female between 18 to 68 years of age inclusive capable of giving written informed consent

Exclusion criteria

Exclusion criteria: Use of nasal corticosteroids within 4 weeks before participation and during study Nasal conditions likely to effect the outcome of the study, i.e. nasal malformations Use of intranasal medication to treat nasal symptoms Nasal or sinussurgery in the previous three months Use of antihistamines in the 48 hours before each visit Recent upper airway infection Serious or unstable co-morbidity A diagnosis of asthma Pregnant or lactating females Past medical history of nasal polyposis Smoking Inability to follow the instructions or completing all studyprocedures

Design outcomes

Primary

Measure	Time frame
1. The difference between clinical and local inflammatory reaction to non-specific stimuli in nasal provocation tests in nonallergic rhinitis patients, mixed rhinitis patients, perennial allergic patients and healthy individuals 2. The difference in reaction between nonallergic rhinitis patients, mixed rhinitis patients, perennial allergic patients and healthy individuals to nasal provocation tests 3. The difference in reaction between chemical and physical non-specific stimuli and airborne allergen in nasal provocation tests in nonallergic rhinitis patients, mixed rhinitis patients, perennial allergic rhinitis patients and healthy individuals. 4. The differences between the genetic expression profile of rhinitis at RNA level in nonallergic rhinitis, mixed rhinitis, allergic rhinitis patients and healthy individuals using the Affymetrix micro-array technology	—

Measure

Time frame

1. The difference between clinical and local inflammatory reaction to non-specific stimuli in nasal provocation tests in nonallergic rhinitis patients, mixed rhinitis patients, perennial allergic patients and healthy individuals 2. The difference in reaction between nonallergic rhinitis patients, mixed rhinitis patients, perennial allergic patients and healthy individuals to nasal provocation tests 3. The difference in reaction between chemical and physical non-specific stimuli and airborne allergen in nasal provocation tests in nonallergic rhinitis patients, mixed rhinitis patients, perennial allergic rhinitis patients and healthy individuals. 4. The differences between the genetic expression profile of rhinitis at RNA level in nonallergic rhinitis, mixed rhinitis, allergic rhinitis patients and healthy individuals using the Affymetrix micro-array technology

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)