mentale stress mental challenge psychological/mental stress
Conditions
Interventions
Intervention:
Daily consumption of two cans (66 cl) of beer (~26 g alcohol/day)
or two cans of non-alcohol beer (66 cl) for two weeks.
Sponsors
Stichting Alcohol Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 9.4 Inclusion criteria 1. Healthy as assessed by the health and lifestyle questionnaire (P8749 F02), physical examination and results of the pre-study laboratory tests 2. Males aged 21-40 years at Day 01 of the study. 3. Body Mass Index (BMI) of 18 - 27 kg/m2. 4. Alcohol consumption >= 5 and
Exclusion criteria
Exclusion criteria: 9.5 Exclusion criteria Subjects with one or more of the following characteristics will be excluded from participation: 1. Participation in any clinical trial including blood sampling and/or administration of substances up to 90 days before Day 01 of this study. 2. Participation in any non-invasive clinical trial up to 30 days before Day 01 of this study, including no blood sampling and/or oral, intravenous, inhalatory administration of substances. 3. Having a history of medical or surgical events or disease that may significantly affect the study outcome, particularly psychological disorders or psychiatric, metabolic or endocrine disease and gastrointestinal disorders. 4. Use of medication that may affect the outcome of the study parameters. 5. Having a family history of alcoholism. 6. Smoking. 7. Not having appropriate veins for blood sampling/cannula insertion according to TNO. 8. Reported unexplained weight loss or gain in the month prior to the pre-study screening. 9. Reported slimming or medically prescribed diet. 10. Reported vegan, vegetarian or macrobiotic. 11. Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stress response: Effect of acute alcohol consumption shortly after a psychological/mental stressor: - Plasma hormones of the HPA axis (cortisol, ACTH, CRH), and - Plasma cytokines (TNFa, IL6), - Endocannabinoids. Cholinergic status: Cholinergic status after prolonged moderate alcohol consumption. | — |
Secondary
| Measure | Time frame |
|---|---|
| FAAH activity: FAAH activity in both adipose tissue and blood after prolonged moderate alcohol consumption. Endocannabinoids: Endocannabinoid and related N-acyl ethanolamine production in adipose tissue after prolonged moderate alcohol consumption. | — |
Countries
Netherlands
Outcome results
None listed