common cold upper respiratory tract infection (URTI)
Conditions
Interventions
Subjects will either start with colostrum supplementation or placebo (skimmed
milk powder). After a wash out period of 3 weeks the other supplement will be
taken. The colostrum is 12h bovine colostr
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male cyclists/triathletes with at least 2 years of cycling experience. - Cycling at least 3 times a week during peak season. - 18 - 35 years old. - Body mass index (BMI) 20 - 25 kg/m2.
Exclusion criteria
Exclusion criteria: - Known symptoms of milk allergy. - Known symptoms of immune disease. - Symptoms of infections during the last month before the start of the experiment. - Smoking. - Use of more than 2 alcoholic consumptions per day during the last 2 weeks before the start of the experiment and during the experiment itself. - Use of drugs. - Use of colostrum during the last month before the start of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The immune function will be assessed by measuring changes in several markers, i.e. salivary IgA level, plasma immunoglobulins and cytokines, number of lymphocytes, neutrophils and natural killer cells and plasma cortisol concentration. In addition, in vitro cell proliferation, cytokine production and apoptosis in peripheral blood mononuclear cells (PBMCs) will be measured. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in circulating metabolites and endocannabinoids serve as secundary study parameters. | — |
Countries
Netherlands
Outcome results
None listed