EVALUATION OF THE USE OF VACCINES AGAINST EPIDEMIC FLU AND THE PRESENCE OF CROSSREACTIVE T CELL RESPONSES AGAINST POTENTIALLY PANDEMIC INFLUENZA VIRUSES IN CHILDREN

EVALUATION OF THE USE OF VACCINES AGAINST EPIDEMIC FLU AND THE PRESENCE OF CROSSREACTIVE T CELL RESPONSES AGAINST POTENTIALLY PANDEMIC INFLUENZA VIRUSES IN CHILDREN - CTL immunity against influenza in children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32610

Enrollment

Registered

2009-11-04

Start date

2009-11-10

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

crossreactive T-cell responses Influenza

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: - Age: children between 3-8 years old - Vaccinated against influenza on an annual basis (CF-patients): group 1 - Not vaccinated against influenza: group 2

Exclusion criteria

Exclusion criteria: -Immune deficient children (e.g. due to haematological, genetic disorders or iatrogenic) - Children that chronically receive immunosuppressive medications - Children with diabetes

Design outcomes

Primary

Measure	Time frame
Comparison of CTL immunity in two different groups of children: Main study parameters/endpoints: The main study parameter will be the number of virus specific -CD8+ T cells in the peripheral blood of children of the two study groups. Data for this parameter can be obtained after collecting a single blood sample of 5 millilitres.	—

Secondary

Measure	Time frame
Seroincidence of influenza in children with CF	—

Countries

Netherlands

Outcome results