Diabetes mellitus hyperglycaemia
Conditions
Interventions
Hyperglycaemic clamp. The plasma glucose concentration will be elevated in a
stepwise manner by administration of somatostatin, glucose and insulin
(fasting, 6 mmol/l, 8 mmol/l and 10 mmol/l).
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male Caucasian race Age 18-30 years
Exclusion criteria
Exclusion criteria: Diabetes mellitus or fasting glucose >5.5 mmol/l Smoking BMI > 25 kg/m2 Blood pressure >= 130 mmHg systolic; >= 90 mmHg diastolic Total cholesterol >= 5 mmol/l, LDL-cholesterol >= 3 mmol/l or triglycerides >= 1.7 mmol/l Use of lipid lowering or antihypertensive drugs Use of antioxidants in the two weeks before the hyperglycemic clamp Acute illness within 3 months before the study Any other illness that inhibits participation in the study according to the study physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relation between level of glycemia and glycocalyx thickness, relation between level of glycemia and ROS formation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relation between glycocalyx thickness and ROS formation, relation between level of glycemia and activation of coagulation parameters. | — |
Countries
Netherlands
Outcome results
None listed