anovulation subfertility
Conditions
Sponsors
Medisch Spectrum Twente
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Patients with six ovulatory cycles after CC treatment and no conception. Ovulation is assessed by a midluteal progesterone (> 16 nmol/l), basal temperature curve, detection of LH surge or history. • All patients have normal serum FSH ( 80 pmol/l), prolactin (0,05 - 0,80 IU/l) and thyroid-stimulating hormone (0,4 - 4,0 mU/l). • All women have patent Fallopian tubes, proven by hysterosalpingography (HSG), a negative Chlamydia antibody titre (CAT) or diagnostic laparoscopy combined with tubal testing (DLS and TT). • The partners have normal semen parameters according to the modified criteria of the World Health Organization (1999). • Age between 18 and 40 years.
Exclusion criteria
Exclusion criteria: • Patients who have previously been treated with gonadotropins or IVF are excluded. • Patients are excluded if they have intolerable symptoms when treated with CC like hot flashes affecting daily function, headaches, vision changes, and depression • Patients are excluded if they are remaining anovulatory on CC 150 mg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy leading to live birth. | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical pregnancy miscarriage multiple pregnancy occurrence of ovulation. | — |
Countries
Netherlands
Outcome results
None listed