Evaluation of dynamic MRI with T1-maps correlated with histopathology in patients with Crohn's Disease

Evaluation of dynamic MRI with T1-maps correlated with histopathology in patients with Crohn's Disease - Dynamic MRI correlated with histopathology in patients with Crohn's Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32582

Enrollment

Registered

2009-01-19

Start date

2009-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's disease inflammatory bowel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Crohn's Disease Scheduled for elective surgery of the small bowel > 18 years old

Exclusion criteria

Exclusion criteria: general contraindications for MRI (pacemaker, pregnancy, renal insuffiency, claustrophobia)

Design outcomes

Primary

Measure	Time frame
The main study parameter will be the accuracy of detecting disease activity and efficacy of DCE MRI with T1 mapping and DWI at MR in patients with proven Crohn*s disease as compared to histopathology.	—

Secondary

Measure	Time frame
1. To determine the correlation between Gadolinium concentration of the pathological bowel wall and histopathological activity. 2. To determine the correlation between enhancement curves at DCE-MRI and CDAI, CRP. 3. To determine the correlation between Gadolinium concentration of the pathological bowel wall and CDAI, CRP. 4. To determine the correlation between histopathology and enhancement patterns of the colonic wall. 5. To determine the correlation between histopathology and DWI.	—

Measure

Time frame

1. To determine the correlation between Gadolinium concentration of the pathological bowel wall and histopathological activity. 2. To determine the correlation between enhancement curves at DCE-MRI and CDAI, CRP. 3. To determine the correlation between Gadolinium concentration of the pathological bowel wall and CDAI, CRP. 4. To determine the correlation between histopathology and enhancement patterns of the colonic wall. 5. To determine the correlation between histopathology and DWI.

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Countries

Netherlands

Outcome results