Methods to examine intestinal permeability under different conditions.

Methods to examine intestinal permeability under different conditions. - Intestinal permeability.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32575

Enrollment

Registered

2010-01-12

Start date

2010-01-25

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

darmdoorlaatbaarheid wordt gemeten in gezonde mannen intestinal permeability irretable bowel syndrome

Interventions

On two different test days eight lean and eight obese men will be supplied with a sugar drink to examine intestinal permeability under normal conditions and in combination with an oral fat load to e

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Healthy as assessed by the - health and lifestyle questionnaire (P8738 F02; in Dutch) - results of the pre-study laboratory tests 2. Males aged >= 18 and = 20 and = 30 and

Exclusion criteria

Exclusion criteria: 1. Participation in any clinical trial including blood sampling and/or administration of substances up to 30-90 days before Day 01 of this study 2. Participation in any non-invasive clinical trial up to 30 days before Day 01 of this study, including no blood sampling and/or oral, intravenous, inhalator administration of substances 3. Having a history of medical or surgical events that may significantly affect the study outcome, including cardiovascular disease or hypertension, stomach and intestinal complaints (and medication), pre-diabetes and Diabetes Mellitus 4. Having stomach and/or intestinal complaints after consumption of a high-fat meal 5. Usage of NSAIDs and/or acetylsalicyl acid (for example ibuprofen, diclofenac, naproxen or aspirin) 6. Smoking 7. Alcohol consumption ( > 28 units/week) 8. Reported unexplained weight loss or gain of > 2 kg in the month prior to the pre-study screening 9. Reported slimming or medically prescribed diet 10. Recent blood donation (

Design outcomes

Primary

Measure	Time frame
Intestinal permeability will be examined with an absorption test using four different sugars (sucrose, mannitol, sucralose and lactulose). New markers of intestinal permeability, like I-FABP, L-FABP, LPS and inflammatory markers will be measured as well.	—

Secondary

Measure	Time frame
Trait Anxiety inventory (baseline stress level as a character trait). Body resistance in relation with intestinal permeability.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)