FindTrial
Sign In

Early detection and monitoring of articular cartilage damage following knee trauma

Early detection and monitoring of articular cartilage damage following knee trauma - Early detection of cartilage damage

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON32552
Enrollment
10
Registered
2008-12-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cartilage degeneration Focal cartilage lesions

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Patients must be older than 18 years of age. -Patients must have an acute or recent (

Exclusion criteria

Exclusion criteria: -Patients with diagnosed inflammatory rheumatic disease. -Not trauma related hemathrosis. -Contra-indications for gadolinium contrast MRI (abnormal kidney function)

Design outcomes

Primary

MeasureTime frame
Primary study parameter will be the change in dGEMRIC value at 4 and 12 months after the trauma as related to the first (—

Secondary

MeasureTime frame
Secondary parameters of this study will be the intraarticular changes after knee trauma as related to the clinical and functional condition of the patient (measured with specific questionnaires). We will use a correlation analysis to determine the association between the clinical condition of the patient and (changes in) cytokine spectrum, biomarkers and proteoglycan content (as parameters of cartilage quality)—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)