atopic dermatitis eczema
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Atopic dermatitis patients: - Adult (18-70 years of age) male or female patients diagnosed with atopic dermatitis - Positive APT to house dust mite allergen - Biopsy location (~4 cm2) should not be treated with topical steroids for at least 1 week - No use of oral antihistamines in the 2 weeks prior to inclusion;Psoriasis vulgaris patients: - Adult (18-70 years of age) male or female patients diagnosed with psoriasis vulgaris - Biopsy location (~4 cm2) should not be treated with topical steroids for at least 1 week;Healthy controls: - Adult (18-70 years of age) male or female volunteers without a history of skin diseases - Biopsy location (~4 cm2) should not be treated with topical steroids for at least 1 week - No history of asthma and/or hay fever
Exclusion criteria
Exclusion criteria: - Use of systemic immunosuppressive drugs (i.e., cyclosporin, prednisolone, methotrexate, neotigason, fumaric acid) in the 6 weeks prior to inclusion - Exposure of biopsy location to (extraordinary) UV sunlight (i.e. UV-therapy, sunny holiday) in the weeks prior to inclusion - (Secondary) skin infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will determine the percentage of CD8+ IL-13-producing skin resident T cells in acute and chronic AD using the APT as an in vivo model. Results will be compared to data from lesional and non-lesional AD, PV skin and healthy control skin. | — |
Countries
Netherlands
Outcome results
None listed