Barrett esophagus heartburn
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age 18-85 years; * Circumferential Barrett segment of 3-8 cm; * Scheduled for primary circumferential RFA of Barrett epithelium with flat low-grade or high-grade intraepithelial neoplasia, or residual Barrett epithelium (with or without neoplasia) after prior endoscopic resection for lesions containing high-grade intraepithelial neoplasia and/or cancer; * No esophageal stricturing, defined as difficulties when passing a therapeutic endoscope; * Written informed consent.
Exclusion criteria
Exclusion criteria: * In the case of an endoscopic resection, histological evaluation showing: signs of deep submucosal infiltration (>T1sm1), poorly or undifferentiated cancer, irradical resection at the deep resection margin, or lymphatic/vascular invasion; * Visible lesions in the Barrett segment prior to RFA; * Any biopsy with residual cancer after the endoscopic resection; * Unable to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Morphological stages of the epithelium during the squamous regeneration process after RFA. 2. Expression of relevant proteins in the epithelium during the squamous regeneration process after RFA. 3. Presence of loss of heterozygosity and single-nucleotide polymorphisms in the regenerating NSE, in the submucosal gland ducts in BE, and in normal squamous epithelium. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Morphological characteristics of NSE compared to untreated squamous epithelium. 2. Expression of relevant proteins with immunohistochemical staining in NSE and in untreated squamous epithelium. | — |
Countries
Netherlands
Outcome results
None listed