balloon-like dilatation of blood vessels in the brain intracranial aneurysm
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -patients with ruptured aneurysms, who received an endovascular treatment in one of the participating centers, between August 1st 2008 and December 1st 2010. -patients with unruptured and untreated aneurysms, whose aneurysms where found incidentally in one of the participating centers -patients with an aneurysm who underwent a 3D rotational angiography as part of the standard clinical care. -age between 18-75 -Glasgow Outcome Score(GOS) full recovery/ moderate disability -written informed consent
Exclusion criteria
Exclusion criteria: Contraindications for MRI (pacemakers, claustrophobia etc. ) previous surgical treatment of an aneurysm with neurosurgical clips
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study parameters: 1) MRI measurements of flow velocity (in cm/s) in blood vessels proximal and distal of intracranial aneurysms. 2) Development of patient-specific hemodynamic models using CFD. 3) Geometrical data acquired through 3D rotational angiography. Endpoints: 1) The influence of the 4 geometric and 4 hemodynamic parameters on aneurysm rupture status. 2) The relative contribution of the individual parameters (all parameters as independents) in predicting aneurysm rupture status (dependent), 3) Selection of parameters to build models in which aneurysm rupture can be best predicted. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters: development of patient-specific hemodynamic models using CFD Secundary outcome: selection of characteristics to build models in which aneurysm rupture can be best predicted. | — |
Countries
Netherlands
Outcome results
None listed