mild hypercholesterolaemia slightly elevated cholesterol
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy male and female subjects, aged 18-65 years old, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l, who participated in the Dahlia-1 study and belong to the 6 subjects with the highest or to the 6 subjects with the lowest plasma campesterol levels respectively. One subject with the subsequently highest campesterol levels will be asked to undergo a cholesterolabsorption measurement as well, in order for us to test the quantification of cholesterol isotopes by our laboratory.
Exclusion criteria
Exclusion criteria: Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident, will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in fractional cholesterol absorption, as measured by means of the dual isotope method, between subjects with high and low plasma campesterol levels respectively. | — |
Countries
Netherlands
Outcome results
None listed