On the Role of The (Pro)Renin-Angiotensin System in Preeclampsia

On the Role of The (Pro)Renin-Angiotensin System in Preeclampsia - RAS in preeclampsia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32502

Enrollment

120

Registered

2009-11-26

Start date

2010-03-15

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preeclampsia toxicosis of pregnancy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: pregnant women who undergo a caesarian section. women with and without preeclampsia and with or withour preexistent or gestational diabetes mellitus are included. Non-pregnant women who undergo abdominal gynaecological surgery

Exclusion criteria

Exclusion criteria: Not willing to give informed consent Use of antihypertensive medication

Design outcomes

Primary

Measure	Time frame
To assess whether concentrations of renin and prorenin in the circulation and amniotic fluid change during preeclampsia and whether circulating and amniotic fluid concentrations are inversely related. To assess whether concentrations of renin and prorenin are infuenced by diabetes mellitus. To assess the gene expression of components of the RAS, including the (pro)renin-receptor in the maternal and foetal part of the placenta and the influence of preeclampsia and diabetes mellitus. To assess the functional role of (pro)renin-receptors in the endometrium. To assess the influence of pregnancy and preeclampsia on the role of the angiotensin II, subtype 2 receptor.	—

Measure

Time frame

To assess whether concentrations of renin and prorenin in the circulation and amniotic fluid change during preeclampsia and whether circulating and amniotic fluid concentrations are inversely related. To assess whether concentrations of renin and prorenin are infuenced by diabetes mellitus. To assess the gene expression of components of the RAS, including the (pro)renin-receptor in the maternal and foetal part of the placenta and the influence of preeclampsia and diabetes mellitus. To assess the functional role of (pro)renin-receptors in the endometrium. To assess the influence of pregnancy and preeclampsia on the role of the angiotensin II, subtype 2 receptor.

—

Countries

Netherlands

Outcome results