arteriosclerosis hardening of the arteries insulin resistance syndrome
Conditions
Interventions
The test meals are provided as cupcakes. In the butter meal 61,65g butter is
added to 60g flower, 60g sugar and 60g of whole egg. In the margarine meal 50g
margarine in combination with 10g safflowe
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: men BMI in the range of 25-30 kg/m2 age between 18 and 70 no treatment with lipid-lowering (Dutch Cholesterol Concensus)
Exclusion criteria
Exclusion criteria: - Women - Plasma triacylglycerol >= 1.7 mmol/L (150 mg/dL) - Smoking - Lipid-lowering medication/therapy - Familial hypercholesterolemia - Use of drugs - Alcohol consumptions >14/week - Unstable body weight (weight gain or loss > 3 kg in the past three months) - Severe medical conditions, which might interfere with the study, such as epilepsy, asthma, COPD, inflammatory bowel diseases and rheumatoid arthritis. - Active CVD or recent event in the past 6 months (acute myocardial infarction, stroke) - Participation in another intervention study within 1 month preceding the screening visit - Blood donation within 1 month prior to the screening visit or planning to do so during the study - Impossible or difficult venapunction during screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study endpoints are levels of interleukin-6 and levels of other markers of postprandial inflammation, including TNF-alpha, MCP-1, interleukin-1 and interleukin-8. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include markers of insulin resistance, plasma lipids and lipoproteins. | — |
Countries
Netherlands
Outcome results
None listed