Structural and functional connectivity in relation to cognitive and social functioning of children with Neurofibromatosis Type 1

Structural and functional connectivity in relation to cognitive and social functioning of children with Neurofibromatosis Type 1 - Brain-behavior relationships in NF1

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32474

Enrollment

Registered

2010-04-23

Start date

2010-10-31

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Von Recklinghausen's Disease

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: General inclusion criteria: age between 9 and 13 at time of study; Dutch speaking and signed informed consent from parents and participants. NF1 participants fulfill the diagnostic criteria specified by the National Institutes of Health Consensus Conference (National Institutes of Health, 1988), i.e. they meet two or more of the following criteria: six or more café-au-lait spots, two or more neurofibromas, skinfold freckling, an optic glioma, two or more Lisch nodules, or a first degree relative with NF1.

Exclusion criteria

Exclusion criteria: -history of psychiatric illness (other than ADHD), closed-head injury, endocrinological dysfunction, or neurological illness (other than NF1). Use of psychotropic medication (other than stimulants to treat ADHD-symptomatology). Many individuals with NF1 receive an ADHD-diagnosis (there are reports of an ADHD-incidence of up to 40-50% in NF1). Most of them will receive stimulant medication. Because of the high incidence we will not exclude individuals with an ADHD-diagnosis. Instead, we will control for ADHD and use of stimulant medication in our analyses. -contraindications for fMRI -premature birth

Design outcomes

Primary

Measure	Time frame
Task performance, questionnaire data on social functioning, white matter integrity (i.e. Fractional Anisotropy (FA) measured with Diffusion Tensor Imaging (DTI) scan), T1-images to assess gray and white matter volumes (measured with structural anatomy scan), T2-images to assess activity (i.e. blood oxygen level dependent (BOLD) responses) during tasks (measured with functional MRI scans), and measures of functional connectivity between brain regions (cross-correlations), based on activity measured during the resting state scan and during task performance (i.e. using the fMRI-scans).	—

Measure

Time frame

Task performance, questionnaire data on social functioning, white matter integrity (i.e. Fractional Anisotropy (FA) measured with Diffusion Tensor Imaging (DTI) scan), T1-images to assess gray and white matter volumes (measured with structural anatomy scan), T2-images to assess activity (i.e. blood oxygen level dependent (BOLD) responses) during tasks (measured with functional MRI scans), and measures of functional connectivity between brain regions (cross-correlations), based on activity measured during the resting state scan and during task performance (i.e. using the fMRI-scans).

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Secondary

Measure	Time frame
Performance and verbal IQ estimations as measured by Block Patterns and Word Knowledge from the WISC. Behavior data from the Child Behavior Checklist.	—

Countries

Netherlands

Outcome results