Preventie van osteoporosis en arteriosclerosis Osteoporosis and vascular calcifications
Conditions
Interventions
Participants will be randomly divided to receive
casein capsules (1
capsule/d), Arabic gum capsules (1 capsule/d), or linseed oil capsules (1
capsule/d). All capsules will be enriched with 90 µg MK-7. One week before the
start of the study and du
Sponsors
VitaK
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Healthy men and women aged between 20 and 40 y • Normal body weight and height (BMI
Exclusion criteria
Exclusion criteria: • (A history of) metabolic or gastrointestinal diseases • Chronic degenerative and/or inflammatory diseases • Abuse of drugs and/or alcohol • Use of corticosteroids • Use of oral anticoagulants • (A history of) soy, milk, or natto allergy • Use of vitamin K-containing multivitamins or vitamin K supplements • Anaemia • Blood donation or participation in another study within one month before the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main purpose of the study is to compare the absorption of MK-7 from casein capsules (conventional MK-7 delivery system), Arabic gum capsules (alternative MK-7 delivery system), and linseed oil capsules in healthy subjects. The primary endpoint will be the serum level of MK-7. | — |
Secondary
| Measure | Time frame |
|---|---|
| The second purpose of the study is to determine the biological functionality of the different delivery systems. Therefore, the secondary endpoint will be the level of several circulating biochemical markers (cMGP, ucMGP, cOC, ucOC). | — |
Countries
Netherlands
Outcome results
None listed