Measuring the Mirror Neuron System: A Combined EEG/fMRI Study

Measuring the Mirror Neuron System: A Combined EEG/fMRI Study - Measuring the Mirror Neuron System

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32442

Enrollment

Registered

2010-01-08

Start date

2019-07-23

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gezonde proefpersonen it is a healthy subject study

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Healthy males and females 2. Between 18 - 40 years old 3. Normal vision and hearing 4. Right-handed

Exclusion criteria

Exclusion criteria: 1. MR incompatible implants in the body (through questionnaire) 2. Neurological complaints present as well as past (through questionnaire) 3. Use of drugs that may influence the task performance (through questionnaire) 4. Claustrophobia (through questionnaire) 5. Wishes not to be informed of brain abnormalities that may be noticed in the scans 6. (Suspected) Pregnancy 7. Tattoos containing red pigments

Design outcomes

Primary

Measure	Time frame
The main analysis strategy will be as follows. First, we will use a general linear model to identify voxels in the brain that have a BOLD signal which is negatively correlated with the power in the EEG signal within the alpha (8-13 Hz) and beta (13-30 Hz) range during the observation and the execution conditions. These maps will then be compared with those obtained from a classical fMRI identification of the mirror neuron system (i.e. (complex action observation * complex control observation) and (complex action execution * complex control execution)) to test if the neural correlates of alpha and/or beta suppression indeed coincide with the mirror neuron system. Finally, we will use the passive and active manipulation of a ball conditions to examine the contribution to the EEG signal of proprioceptive brain regions that should be similarly involved in both conditions and of motor brain regions that should be more involved in the active manipulation condition. Finally, the resting state fMRI condition will be used to examine the degree to which somatosensory and motor brain regions are connected and these parameters will be compared to the correlation between the power in the alpha and beta range.	—

Measure

Time frame

The main analysis strategy will be as follows. First, we will use a general linear model to identify voxels in the brain that have a BOLD signal which is negatively correlated with the power in the EEG signal within the alpha (8-13 Hz) and beta (13-30 Hz) range during the observation and the execution conditions. These maps will then be compared with those obtained from a classical fMRI identification of the mirror neuron system (i.e. (complex action observation * complex control observation) and (complex action execution * complex control execution)) to test if the neural correlates of alpha and/or beta suppression indeed coincide with the mirror neuron system. Finally, we will use the passive and active manipulation of a ball conditions to examine the contribution to the EEG signal of proprioceptive brain regions that should be similarly involved in both conditions and of motor brain regions that should be more involved in the active manipulation condition. Finally, the resting state fMRI condition will be used to examine the degree to which somatosensory and motor brain regions are connected and these parameters will be compared to the correlation between the power in the alpha and beta range.

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Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results