The effects of Acute Tryptophan Depletion in individuals with a history of depression with and without anger attacks

The effects of Acute Tryptophan Depletion in individuals with a history of depression with and without anger attacks - Serotonin and depression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32412

Enrollment

Registered

2009-01-19

Start date

2009-04-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression

Interventions

The day before the session, all subjects will be instructed to fast from midnight. The ATD mixture is similar to the one in Young et al. (1985), known to decrease tryptophan levels by by 70 to 90% w

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age between 18 and 65 years; - Meeting DSM-IV criteria for past depression as a primary diagnosis; - Having at least 2 episodes of past depression OR having at least one first-degree relative with recurrent MDD; - A Hamilton depression rating scale (HDRS)-score lower than 10 OF MADRS

Exclusion criteria

Exclusion criteria: - Major physical illness; - Substance abuse within the last 3 months; - Lactation - Pregnancy; - History or current Psychotic Disorder or Bipolar Disorder; - Using medication likely to affect CNS function, incl. benzodiazepines

Design outcomes

Primary

Measure	Time frame
The primary outcome measure is change in symptoms following ATD compared to placebo (MADRS and Spielberger State anger as primary measures);	—

Secondary

Measure	Time frame
serotonin transporter and polymorphisms of the 5-Ht1A C(-1019)G gene and the mineralocorticoid and glucocorticoid receptor-genes	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)