insulin sensitivity insuline resistance
Conditions
Interventions
Intervention: Daily consumption of 0.25L of dry white wine (12.5% vol.
25 gram
alcohol/day) or 0.25L of water (control) for four weeks.
Sponsors
Stichting Alcohol Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Healthy as assessed by the health and lifestyle questionnaire (P8009 F02), physical examination and results of the pre-study laboratory tests 2. Caucasian females aged > 46 and * 65 years at Day 01 of the study. 3. Body Mass Index (BMI) of 18 - 26 or 27 - 35 kg/m2. 4. Postmenopausal as assessed by self reported absence of menstrual periods for at least 12 months. 5. Alcohol consumption >= 5 and
Exclusion criteria
Exclusion criteria: Subjects with one or more of the following characteristics will be excluded from participation: 1. Participation in any clinical trial including blood sampling and/or administration of substances up to 90 days before Day 01 of this study. 2. Participation in any non-invasive clinical trial up to 30 days before Day 01 of this study, including no blood sampling and/or oral, intravenous, inhalatory administration of substances. 3. Having a history of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disease and gastrointestinal disorders. 4. Use of medication that may affect the outcome of the study parameters. 5. Having a family history of alcoholism. 6. Smoking. 7. Not having appropriate veins for blood sampling/cannula insertion according to TNO. 8. Reported unexplained weight loss or gain in the month prior to the pre-study screening. 9. Reported slimming or medically prescribed diet. 10. Reported vegan, vegetarian or macrobiotic. 11. Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cephalic phase reflex: Pancreatic polypeptide (PP) in serum. Gene expression in adipose tissue: Gene expression pathways related to inflammation, insulin sensitivity and lipid and carbohydrate metabolism in subcutaneous adipose tissue | — |
Secondary
| Measure | Time frame |
|---|---|
| Markers of inflammation, insulin sensitivity and lipid metabolism: - Adiponectin (both total and HMW) and cytokines in plasma; - Cytokines excreted from Peripheral Blood Mononuclear Cells (PBMC) after in vitro stimulation with inflammatory agents. | — |
Countries
Netherlands
Outcome results
None listed